1-Methylpiperidine-4-carboxylic acid → HCID 178480347, compound

HRID 1909416Notes

Reaction equation

HRID 1909416 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[CH3:26][N:27]1[CH2:32][CH2:31][CH:30]([C:33](O)=[O:34])[CH2:29][CH2:28]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:33]([CH:30]5[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]5)=[O:34])[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 27369391-Methylpiperidine-4-carboxylic acidHCID 178479251HCID 178479251, compound2×

Product 1

HCID 178480347HCID 178480347, compound

Procedure

The title compound, white solid (26.9 mg, 69.5%), MS (ISP) m/z=456.3 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (31.2 mg, 0.085 mmol) and 1-methylpiperidine-4-carboxylic acid.

Sources & evidence

ORD record
ord-149379305cbb4f379defc282461d98e3
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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