HCID 178479251, compound → HCID 178496548, compound

HRID 1909418Notes

Reaction equation

HRID 1909418 reaction equation
Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[CH3:26][O:27][C@H:28]1[CH2:33][CH2:32][C@H:31]([CH2:34][C:35](O)=[O:36])[CH2:30][CH2:29]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH:19]4[CH2:20][CH2:21][CH:22]([NH:25][C:35](=[O:36])[CH2:34][C@H:31]5[CH2:32][CH2:33][C@H:28]([O:27][CH3:26])[CH2:29][CH2:30]5)[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

Participants

3

Reactant 2

HCID 178479251HCID 178479251, compound2×HCID 178496559HCID 178496559, compound

Product 1

HCID 178496548HCID 178496548, compound

Procedure

The title compound, white solid (30.8 mg, 77.7%), MS (ISP) m/z=485.4 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (31.2 mg, 0.085 mmol) and trans-(4-methoxycyclohexyl)acetic acid synthesized as described in W2009/013212 p. 73.

Sources & evidence

ORD record
ord-1523410447714587906b4e6e39663b8e
Source dataset
uspto-grants-2013_12
Patent number
US08598357B2

Reaction notes

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