Potassium Carbonate → HCID 11482333, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of Compound 6 (0.202 g, 1 mmol) in acetonitrile was added K2CO3 (2 equiv.) followed by iodopropanol (0.186 g, 1 mmol). The reaction mixture was stirred at 65° C. overnight. On completion of the reaction, the reaction mixture was filtered and solvent was evaporated under vacuum. The residue was dissolved in water and extracted three times with CH2Cl2. The combined organic extracts were dried over Na2SO4, filtered, and concentrated in vacuum. The resulting compound 12 was purified by column chromatography (2:100, CH3OH/CH2Cl2). Yield: (85%)

Provenance & Evidence