HRID1909487

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12695679

1H-2-Benzopyran-1,4(3H)-dione

C9H6O3

HCID15114000

未命名化合物

结构：O=C1C(O)=C([C@H]2CC[C@H](c3ccc(Cl)cc3)CC2)C(=O)c2ccccc21

HCID178516894

未命名化合物

PRODUCTS

生成物

$结构：O=C1O/C(=C\C2CCC(c3ccc(Cl)cc3)CC2)C(=O)c2ccccc21$

HCID57382077

未命名化合物

PROCEDURE

实验过程

The present invention provides a new process for the preparation of atovaquone, which process comprises reacting 1H-2-benzopyran-1,4(3H)-dione (compound of formula (III)) with 4-(4-chlorophenyl)cyclohexanecarbaldehyde (compound of formula (IV)) to produce the novel intermediate (3Z)-3-{[4-(4-chlorophenyl)cyclohexyl]methylidene}-1H-2-benzopyran-1,4(3H)-dione (compound of formula (II)) which then undergoes internal rearrangement to produce atovaquone (compound of formula (I)).

WORKUP

后处理

customThe present invention provides a new process