HCID 58566301, compound → HCID 58566716, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of 2-bromo-4-chloro-6-(cyclopentenylmethyl)phenol (518) (5.7 g, 19.8 mmol) and Amberlyst® 15 ion-exchange resin (5.2 g) in toluene (100 mL) was heated at 80° C. for 3 hours. Subsequently, the Amberlyst 15 resin was filtered off and the filtrate was concentrated in vacuo to give 7-bromo-5-chloro-3H-spiro[benzofuran-2,1′-cyclopentane] (519) (5.4 g, 94.9%) as a yellow oil.

Provenance & Evidence