HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1909529Generated: October 26, 2026
3-Fluoro-p-anisaldehyde → Ethyl (E)-3-(3-Fluoro-4-methoxyphenyl)acrylate
https://huagongshe.com/reaction/1909529
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Fluoro-p-anisaldehyde | HCID 67696 | — |
| Reactant | Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester | HCID 70670 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl (E)-3-(3-Fluoro-4-methoxyphenyl)acrylate | HCID 12330260 | 87.8% |
Reaction Steps
The mixture of 3-fluoro-4-methoxybenzaldehyde (5.1 g, 33.0 mmol) and (carbethoxymethylene)triphenylphosphorane (17.2 g, 49.5 mmol) in anhydrous toluene (165 mL) was refluxed at 120° C. under nitrogen for 4 hours. The solvent was removed in vacuo and purified by silica gel chromatography (10-20% EtOAc in hexanes) to provide (E)-ethyl 3-(3-fluoro-4-methoxyphenyl)acrylate (537) (6.5 g, 87.6%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598374B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-58d8a1f227314dc892d5e8a8d436e6ad |
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| Source note | uspto-grants-2013_12 |
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