HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1909537Generated: October 27, 2026
Hydrochloric Acid → 2-[2-(4-Methoxyphenyl)cyclopropyl]acetic acid
https://huagongshe.com/reaction/1909537
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-methoxy-2-(2-(4-methoxyphenyl)cyclopropyl)-N-methylacetamide | HCID 22347607 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[2-(4-Methoxyphenyl)cyclopropyl]acetic acid | HCID 22347608 | 96.1% |
Reaction Steps
The mixture of N-methoxy-2-(2-(4-methoxyphenyl)cyclopropyl)-N-methylacetamide (559) (1.8 g, 7.4 mmol), 2.5N NaOH (15 mL) and EtOH (15 mL) was stirred at 60° C. for 24 hours. The reaction mixture was acidified with HCl and extracted with EtOAc. The organic phase was washed with water, brine, dried over sodium sulfate and concentrated in vacuo to provide 2-(2-(4-methoxyphenyl)cyclopropyl)acetic acid (560) (1.5 g, 96.1%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598374B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-81ea7d9b4f6f46018b841809cedbbe11 |
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| Source note | uspto-grants-2013_12 |
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