Hydrochloric Acid → HCID 69002070, compound

Participants

Reaction Conditions

Reaction Steps

4-[(S)-2-(4-p-Tolyloxy-phenoxymethyl)-pyrrolidin-1-yl]-butyric acid ethyl ester (348 mg, 0.875 mmol) was taken into a mixture of concentrated HCl and Dioxane (1:1, 3 mL). The reaction was heated at 60° C. for 5 h. The reaction was concentrated to dryness under vacuum, and then dried in a vacuum oven at 50° C. for 12 h. The title product (346 mg, 0.853, 97% yield) MS; m/z 405.92, found 370 (M-35HCl); 1H NMR (400 MHz, DMSO-d6) δ1.78-1.8 (m, 2H), 1.90-2.05 (m, 3H), 2.21-2.26 (m, 1H), 2.27 (s, 3H), 2.36-2.40 (m, 1H), 3.10-3.16 (m, 2H), 3.47-3.49 (m, 1H), 3.61-3.70 (m, 1H), 3.86-3.10 (2H), 4.27-4.37 (m, 2H), 6.83-6.49 (m, 2H), 6.96-7.04 (m, 4H), 7.14-7.17 (m, 2H), 10.55 (s, 1H).

Provenance & Evidence