HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 69004848, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl (2S)-2-(hydroxymethyl)piperidine-1-carboxylate | HCID 6933954 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 69004848 | HCID 69004848 | — |
Reaction Steps
A 4M HCl solution in dioxane (30 mL) was added to (S)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (5.12 g, 23.78 mmol). The mixture was stirred at rt for 3 h. The solvent was removed in vacuo to yield the title product as a hydrochloride salt (3.43 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598359B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-c66e70e7c9dc44f88641fa2abcb029e9 |
| Source note | uspto-grants-2013_12 |