HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (r)-Piperidin-2-ylmethanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate | HCID 6933953 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (r)-Piperidin-2-ylmethanol hydrochloride | HCID 67247105 | — |
Reaction Steps
A 4M HCl solution in dioxane (30 mL) was added to (R)-2-Hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (4.65 g, 21.6 mmol). The mixture was stirred at rt for 3 h. The solvent was removed in vacuo to yield the title product as a hydrochloride salt (3.47 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598359B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-891def3f501f403390e67261d0ae1a72 |
| Source note | uspto-grants-2013_12 |