Potassium Carbonate → HCID 69003760, compound

Participants

Reaction Steps

To a 20 mL press resistant vial which contained a suspension of (R)-2-[4-(4-iodo-benzyl)phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (200 mg, 0.4 mmol), pyridine-4-boronic acid (110 mg, 0.8 mmol), palladium(II) acetate (10 mg, 0.05 mmol) and triphenyl phosphine (30 mg, 0.1 mmol) in DME (5 mL) was added potassium carbonate (100 mg, 0.7 mmol), ethanol (0.05 mL) and water (0.05 mL) at rt. The tube was sealed and the mixture was allowed to warm to rt and stir at rt for 30 min and then was heated to 98° C. and stirred at 98° C. for 16 h. After cooled to rt, the mixture was poured onto 200 mL ice-water solution and then extracted with EtOAc (3×30 mL). The combined organic layers were washed with water (2×30 mL) and brine (20 mL). and dried over anhy. Na2SO4. The solvent was removed in vacuo to obtain the crude product which was purified by silica gel flash chromatography to afford the title product (100 mg, 60%); 1H NMR (400 MHz, CDCl3); δ 1.47 (s, 9H), 1.79-2.08 (m, 4H), 3.27-3.44 (m, 2H), 3.70-3.96 (m, 1H), 3.97 (s, 2H), 4.04-4.20 (m, 2H), 6.82-6.86 (m, 2H), 7.11 (d, J=8.8 Hz, 2H), 7.29 (d, J=8.4 Hz, 2H), 7.48 (d, J=6.0 Hz, 2H), 7.56 (d, J=8.4 Hz, 2H), 8.63 (d, J=6.0 Hz, 2H):

Provenance & Evidence