HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Iodophenyl)-1H-Pyrazole → (r)-2-[4-(4-Pyrazol-1-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Iodophenyl)-1H-Pyrazole | HCID 2776481 | — |
| Reactant | (R)-2-(4-Hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 68999591 | — |
| Product | (r)-2-[4-(4-Pyrazol-1-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 68998060 | 64.3% |
Reaction Steps
Followed the same procedure as that of step 1 in Example 133 with the use of (R)-2-(4-hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (147 mg, 0.5 mmol) and 1-(4-iodo-phenyl)-1H-pyrazole (203 mg, 0.75 mmol) to afford the title product (140 mg, 60% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598359B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-ae856d78c0b64f94aeb6b9837cb7f70f |
| Source note | uspto-grants-2013_12 |