Hydrochloric Acid → HCID 69001366, compound

Participants

Reaction Steps

To a solution of product from step 3 (100 mg, 0.26 mmol) was treated with 5 ml of 4 N HCl in dioxane and stirred for 2 h. The solvent was removed in vacuo, triturated with ether to give the title compound as the hydrochloride salt (35 mg, 42%) MS; m/z 283 (M+H) 99%; 1H NMR (DMSO-d6, 400 MHz) δ 1.78-2.22 (4H, m), 3.20 (2H, m), 3.98 (1H, m), 4.45-4.65 (2H, m), 7.05 (1H, d, J=8.8 Hz), 7.60 (2H, m), 7.69-7.76 (3H, m), 8.14 (1H, dd, J1=2.8 Hz, J2=8.8 Hz), 8.56 (1H, dd, J1=0.8 Hz, J2=2.4 Hz), 9.2 (1NH, s)

Provenance & Evidence