HuagongsheHuagongshe Chemistry Print Report · For research reference only
Monobenzone → HCID 68996846, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Monobenzone | HCID 7638 | — |
| Reactant | Diglyme | HCID 8150 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Iodopyridine | HCID 609492 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 68996846 | HCID 68996846 | 86.5% |
Reaction Steps
The same procedure from Example 143, step 1 was followed using p-benzyloxyphenol (500 mg, 2.5 mmol), Cs2CO3 (1.58 g, 4.85 mmol), 4-iodo pyridine (780 mg, 3.805 mmol), anhydrous dioxane (15 ml), diglyme (34 mg, 0.24 mmol), CuI (17 mg, 0.089 mmol) to give the title compound (600 mg, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598359B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-97deb6f2403c4a7ba30eee2915d3d059 |
| Source note | uspto-grants-2013_12 |