HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-{4-[4-((R)-1-Pyrrolidin-2-ylmethoxy)-phenoxy]-phenyl}-1H-[1,2,4]triazole hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | (R)-2-[4-(4-[1,2,4]Triazol-1-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 69000404 | — |
| Product | 1-{4-[4-((R)-1-Pyrrolidin-2-ylmethoxy)-phenoxy]-phenyl}-1H-[1,2,4]triazole hydrochloride salt | HCID 69001622 | 80% |
Reaction Steps
The title compound (80 mg, 80%) was prepared from the product of step 1 (130 mg, 0.30 mmol) and 4M HCl in dioxane (0.75 ml, 3 mmol) using the procedure of Example 146, step 4; 1HNMR (400 MHz, CD3OD) δ 10.15 (br, 1H), 9.80 (br, 1H), 7.82 (br, 2H), 7.00 (m, 8H), 4.12 (br, 2H), 4.01 (br, 1H), 3.36 (m, 2H), 2.18-1.96 (m, 4H); LC/MS (ESI+) 99%, 337 (100, M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598359B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-7b622e46f2a7485dbd2838573d0457af |
| Source note | uspto-grants-2013_12 |