HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Phenylthiophene-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 5-Bromothiophene-2-carbaldehyde | HCID 78428 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Propan-2-ol--water (1/1) | HCID 21889133 | — |
| Product | 5-Phenylthiophene-2-carbaldehyde | HCID 177053 | 96.1% |
Reaction Steps
A mixture of 5-bromo-thiophene-2-carbaldehyde (2.0 g, 10.5 mmol), phenylboronic acid (1.7 g, 11 mmol), K2CO3 (8.7 g, 62.8 mmol) and 10% Pd/C (0.56 g) in isopropanol/H2O (1:1, 40 mL) was refluxed for 5 h. The reaction mixture was filtered through a pad of Celite. After the isopropanol was removed, the product was collected on a filter, washed with hexane and dried in vacuo to yield the title compound (1.9 g, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598359B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-ff215b38efb242c4937a45c4f5e15d62 |
| Source note | uspto-grants-2013_12 |