Hydrochloric Acid → HCID 58434886, compound

Participants

Reaction Steps

To a solution of ethyl 2-thiopheneacetylaminoacetate (31.77 g, 140 mmol) in anhydrous toluene (190 mL) was added potassium tert-butoxide (20.95 g, 187 mmol). The mixture was heated to reflux for 2 hours. After cooling, it was poured into water (190 mL) and the water phase was isolated and acidified with dilute HCl to about pH 1 (˜70 mL 10% HCl). The pale brown precipitate was filtered, washed with water and dried. Finally, a pale brown solid with some dark brown chunks was obtained (23.8 g, yield 94%). 1H NMR (d6-DMSO, 500 MHz), δ=7.55 (dd, J=3.5, 1.0 Hz, 1H), 7.48 (s, 1H), 7.30 (dd, J=5.0 1.0 Hz, 1H), 7.01 (dd, J=5.0, 4.0 Hz, 1H), 3.88 (s, 2H).

Provenance & Evidence