HCID 70495627, compound → HCID 70495676, compound

Participants

Reaction Steps

4-Dodecyl-thiophene-2-carboxylic acid amide 2 (5.0 g, 16.9 mmol) was mixed with 50 mL of POCl3 and the mixture was heated at reflux temperature for 2 hours before POCl3 was removed by a rotary evaporator. Dichloromethane (100 mL) was added followed by drop-wise addition of ice water (100 mL). The organic layer was washed with 30 mL of water twice before the solvent was removed. The brown oil obtained was purified with a column of silica gel with hexane/dichloromethane (v/v: 1/1) as the eluent. After removal of the solvent, the product was obtained as a yellow oil (2.49 g, 53% yield).

Provenance & Evidence