HCID 70495271, compound → HCID 70496058, compound

Participants

Reaction Steps

To 6-undecyl-thieno[3,2-b]thiophene-2-carboxylic acid amide (4.2 g) was added 30 mL of POCl3 and the mixture was heated to reflux for 2 hours before POCl3 was removed by a rotary evaporator. Dichloromethane (50 mL) was added and then 100 mL of ice water was added dropwise. The organic layer was further washed with 30 mL of water twice and then dried over anhydrous Na2SO4 before the solvent was removed. The obtained brown oil was passed through a column of silica gel with hexane/dichloromethane (v/v, 3/2) as the eluent. The solvent was removed to give a yellow oil (2.3 g, 75.7% yield).

Provenance & Evidence