1,4-Dioxane hydrochloride → HCID 66868374, compound

HRID 1909868Notes

Reaction equation

HRID 1909868 reaction equation
C(OC([NH:8][CH:9]([CH:20]1[CH2:22][CH2:21]1)[C:10]1[CH:19]=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:11]=1)=O)(C)(C)C.[ClH:23].O1CCOCC1>CO>[ClH:23].[NH2:8][CH:9]([CH:20]1[CH2:22][CH2:21]1)[C:10]1[CH:11]=[CH:12][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58306444HCID 58306444, compound

Product 1

HCID 66868374HCID 66868374, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 4-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}benzoate (793 mg), methanol (5 mL), and 4 M hydrogen chloride/dioxane (5 mL) were mixed, followed by stirring at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and then to the residue was added ethyl acetate. The precipitated solid was collected by filtration and dried under reduced pressure to obtain methyl 4-[amino(cyclopropyl)methyl]benzoate hydrochloride (561 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionto the residue was added ethyl acetate
  3. filtrationThe precipitated solid was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-d787a4cdc48c47c5885fa3ba040af4b5
Source dataset
uspto-grants-2013_12
Patent number
US08598355B2

Reaction notes

Loading…