HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1909879Generated: October 31, 2026
Potassium Phosphate, Tribasic → methyl 1-(4-pyridin-2-yl benzyl)-1H-indole-7-carboxylate
https://huagongshe.com/reaction/1909879
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 2-(Dicyclohexylphosphino)biphenyl | HCID 2734216 | — |
| Reactant | 2-Pyridyl Trifluoromethanesulfonate | HCID 3947626 | — |
| Reactant | HCID 58307051 | HCID 58307051 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | methyl 1-(4-pyridin-2-yl benzyl)-1H-indole-7-carboxylate | HCID 58306536 | 57.1% |
Reaction Steps
To methyl 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-1H-indole-7-carboxylate (0.30 g), pyridin-2-yltrifluoromethanesulfonate (0.35 g), tripotassium phosphate (0.49 g), palladium(II) chloride (27 mg), and biphenyl-2-yl(dicyclohexyl)phosphine (0.11 g) were added dioxane (12 mL) and water (3.0 mL), followed by stirring at 100° C. for 4 hours. The reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate=5/1-4/1) to obtain methyl 1-(4-pyridin-2-yl benzyl)-1H-indole-7-carboxylate (0.15 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598355B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-cf64c48e514e45cea79144abe207e379 |
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| Source note | uspto-grants-2013_12 |
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