反应详情

4-Phenyl thiophene-2-methanol (0.21 g), toluene (2.0 mL), and a catalytic amount of pyridine were added, and thionyl chloride (0.16 mL) was added dropwise thereto under ice-cooling. After stirring at room temperature for 3 hours, the reaction mixture was concentrated under reduced pressure, azeotroped with toluene, and dried at 60° C. under reduced pressure to obtain 2-(chloromethyl)-4-phenylthiophene (0.22 g).

1. temperatureunder ice-cooling
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. customazeotroped with toluene
4. customdried at 60° C. under reduced pressure