HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 5-Bromo-4-chloro-7-methyl-7H-pyrrolo(2,3-d)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine | HCID 265829 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromo-4-chloro-7-methyl-7H-pyrrolo(2,3-d)pyrimidine | HCID 66545160 | 95.1% |
Reaction Steps
To 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (12.15 g, 72.5 mmol) in Dichloromethane (DCM) (200 mL) was added NBS (13.55 g, 76 mmol) portionwise, and the reaction mixture was stirred overnight at room temperature. The solvent was evaporated, and the solid was washed with water and dried to afford 5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (17 g) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598156B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-92316150a0524002954de3a3b1b347a4 |
| Source note | uspto-grants-2013_12 |