関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 5-Bromo-4-chlorothieno[2,3-d]pyrimidine | HCID 45480299 | — |
| 生成物 | 5-Bromothieno[2,3-D]pyrimidin-4-amine | HCID 66823898 | 86.3% |
反応手順
A suspension of 5-bromo-4-chlorothieno[2,3-d]pyrimidine (1 g, 4.01 mmol) in concentrated aqueous ammonium hydroxide (150 mL, 3852 mmol) was stirred overnight at 90° C. in a sealed vessel. The reaction was allowed to cool to room temperature and filtered. The white solid in the filter was air dried to afford 5-bromothieno[2,3-d]pyrimidin-4-amine (796 mg). LC/MS (ES) m/z=387.1 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08598156B2 |
|---|
| 出典データセット | uspto-grants-2013_12 |
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| ORD ID | ord-443a428a30dd4020bd5d2bdeacc9c33a |
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| 出典メモ | uspto-grants-2013_12 |
|---|
