HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1910064Generated: October 31, 2026
Ammonium Hydroxide → 5-bromo-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
https://huagongshe.com/reaction/1910064
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-bromo-4-chloro-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidine | HCID 86663686 | — |
| Product | 5-bromo-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 66824063 | 61.5% |
Reaction Steps
To 5-bromo-4-chloro-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidine (185 mg, 0.641 mmol) was added ammonium hydroxide (24.97 μl, 0.641 mmol) in a 25 ml sealable vial and heated at 85° C. over 24 hr. The solid was isolated by filtration and washed with water (5 mL) and dried to give 5-bromo-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (106 mg), which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598156B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-51cfc3000dbb4fd08298e36cd8c7a6eb |
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| Source note | uspto-grants-2013_12 |
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