HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1910159Generated: October 25, 2026
Diisopropylethylamine → HCID 178522489, compound
https://huagongshe.com/reaction/1910159
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 66940442 | HCID 66940442 | — |
| Reactant | HCID 178508178 | HCID 178508178 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178522489 | HCID 178522489 | 11.3% |
Reaction Steps
To a solution of 44 mg (0.2 mmol) of 7-nitro-isoquinoline-3-carboxylic acid in DMF (1 mL) was added 113 mg (0.3 mmol) of HBTU and DIEA (0.3 mL). The mixture was stirred for 10 min and then 40 mg (0.16 mmol) of 2-amino-3H-benzoimidazole-4-carboxylic acid (1H-imidazol-2-yl)-amide (intermediate B) was added. The reaction was heated at 80° C. for 1 h. After the usual work up, the residue was purified by column chromatography eluting with DCM/methanol (v/v=10:1) to afford 8 mg (9%) of 7-nitro-isoquinoline-3-carboxylic acid [7-(1H-imidazol-2-ylcarbamoyl)-1H-benzoimidazol-2-yl]-amide. LCMS: 443 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08598353B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-80b3ab45c485488eb545c0c8081ae57c |
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| Source note | uspto-grants-2013_12 |
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