HCID 66940495, compound → HCID 66940560, compound

HRID 1910160Notes

Reaction equation

HRID 1910160 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([N+:15]([O-])=O)[CH:9]=2)=[O:4]>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10]([NH2:15])[CH:9]=2)=[O:4]

Participants

3

Reactant 1

HCID 66940495HCID 66940495, compound

Product 1

HCID 66940560HCID 66940560, compoundYield 98.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.5 g (2.1 mmol) of 7-nitro-isoquinoline-3-carboxylic acid methyl ester in methanol (25 ml) was hydrogenated according to the general procedure C to provide 0.42 g of 7-amino-isoquinoline-3-carboxylic acid methyl ester in quantitative yield. LCMS: 203 (M+1)+

Sources & evidence

ORD record
ord-00307227b0284166bef0e01fb054febe
Source dataset
uspto-grants-2013_12
Patent number
US08598353B2

Reaction notes

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