HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxyisoquinoline-3-carboxylic acid → 6-Isopropoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxyisoquinoline-3-carboxylic acid | HCID 57306949 | — |
| Reactant | 2-tert-Butyl 3-methyl 6-hydroxy-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate | HCID 57764555 | — |
| Product | 6-Isopropoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid | HCID 66940538 | 9.1% |
Reaction Steps
0.2 g (9.1%, 4 steps) of the 6-isopropoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid was prepared according to procedure described for the synthesis of 6-methoxy-isoquinoline-3-carboxylic acid (in Example 294) starting from 0.67 g (2.18 mmol) of 6-hydroxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester. LCMS: 232 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598353B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-bede91d1ea4d426799c5ff3c4d9db8d6 |
| Source note | uspto-grants-2013_12 |