HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroformate → 5-Methylisatoic anhydride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 2-Amino-5-methylbenzoic acid | HCID 76255 | — |
| Solvent | Acetyl chloride | HCID 6367 | — |
| Product | 5-Methylisatoic anhydride | HCID 294478 | 80% |
Reaction Steps
15.1 g (100 mmol) of 2-amino-5-methyl-benzoic acid was refluxed with 60 mL of ethyl chloroformate for 6 h, and then was refluxed for another 3 h after addition of 60 mL of acetyl chloride. The solid was collected, washed with hexane to give 14.2 g (80%) of the 5-methylisatoic anhydride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598353B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-6458972b70a04a0ea1303cf1dad47ad1 |
| Source note | uspto-grants-2013_12 |