HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoquinoline-3-carboxylic acid → HCID 58724415, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoquinoline-3-carboxylic acid | HCID 124656 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 66940377 | HCID 66940377 | — |
| Product | HCID 58724415 | HCID 58724415 | 75% |
Reaction Steps
0.4 g (75%) of 2-[(isoquinoline-3-carbonyl)-amino]-6-propyl-1H-benzoimidazole-4-carboxylic acid methyl ester was synthesized from 0.25 g (1.4 mmol) of isoquinoline-3-carboxylic acid, 0.6 g (1.6 mmol) of HBTU, and 0.3 g (1.3 mmol) of the above synthesized 2-Amino-6-propyl-1H-benzoimidazole-4-carboxylic acid methyl ester as described in general procedure A. LCMS: 389 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598353B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-b0f30e4818f14d1ba80edb13e8dcef3f |
| Source note | uspto-grants-2013_12 |