HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 5-Bromo-4-chloroisatoic anhydride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 2-Amino-5-bromo-4-chlorobenzoic acid | HCID 19612050 | — |
| Product | 5-Bromo-4-chloroisatoic anhydride | HCID 86608392 | 70% |
Reaction Steps
7.5 g (30 mmol) of 2-amino-5-bromo-4-chloro-benzoic acid was heated under reflux with 18 mL of ethyl chloroformate for 6 h, and was further heated under reflux for another 3 h after addition of 18 mL of acetyl chloride. The solid was collected and washed with hexanes to produce 5.8 g (70%) of 5-bromo-4-chloroisatoic anhydride. LCMS: 277 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598353B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-1263444a71e34fe0ad6152ba025900b2 |
| Source note | uspto-grants-2013_12 |