HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → HCID 178493649, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | methyl 2-amino-1H-benzo[d]imidazole-4-carboxylate | HCID 24730367 | — |
| Reactant | HCID 86608398 | HCID 86608398 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178493649 | HCID 178493649 | — |
Reaction Steps
1.2 g (5.5 mmol) of 2,3-diamino-4,6-difluoro-5-methoxy-benzoic acid was subjected to a similar cyclization condition as illustrated in intermediate A by using 1.7 g (16.5 mmol) of BrCN in methanol to produce 2-amino-5,7-difluoro-6-methoxy-1H-benzoimidazole-4-carboxylic acid. LCMS: 244 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08598353B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-a69577936ece45a3b01014330d455099 |
| Source note | uspto-grants-2013_12 |