HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malic Acid → 2-(2,2-Dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malic Acid | HCID 525 | — |
| Reactant | 2,2-Dimethoxypropane | HCID 6495 | — |
| Reactant | 1,3-Dioxolane | HCID 12586 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(2,2-Dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid | HCID 357864 | — |
Reaction Steps
Marketed DL-malic acid (with the 4 reference on the above schema) is protected in the dioxolane form in toluene reflux, in the presence of 2,2-dimethoxypropane. The reaction is quantitative. The obtained product (with the 5 reference in the above schema) is directly engaged in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08603498B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-aacc42d5197a4e5f98fac2d99752d22f |
| Source note | uspto-grants-2013_12 |