HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 57674668, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Trimethylboroxine | HCID 574072 | — |
| Reactant | 5-Bromo-3,4-dimethylpyridin-2-amine | HCID 7010307 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57674668 | HCID 57674668 | — |
Reaction Conditions
| Temperature | 115 °C |
|---|
Reaction Steps
23.0 g (0.11 mol) of 2-amino-5-bromo-3,4-dimethylpyridine was mixed with 14.1 g (0.11 mol) of trimethylboroxin (TMB), 12.9 g (0.011 mol) of Pd(Ph3)4, 46.0 g (0.33 mol) of K2CO3 and 220 mL of DMF. The reaction mixture was heated under nitrogen at 115° C. for 18 hours. The reaction mixture was purified by silica gel column. The desired product was confirmed by MS.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08603645B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-3f3edfe8ed484aabadaf12a1ead799a3 |
| Source note | uspto-grants-2013_12 |