Hydrochloric Acid → HCID 68535367, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(3-thienyl)-3,6-dihydropyridine-1(2H)-carboxylate (170 mg) in EtOAc (1.7 ml) and water (0.085 ml) was added 4 N hydrogen chloride in EtOAc (1.7 ml) and the mixture was stirred at room temperature for 1 hour. Solvent was removed in vacuo to give 4-(3-thienyl)-1,2,3,6-tetrahydropyridine hydrochloride (120 mg) as a dark gray powder. The obtained crude product was used in next reaction without further purification.

Provenance & Evidence