HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate | HCID 68570558 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride | HCID 68571203 | — |
Reaction Steps
To a solution of tert-butyl 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine-1-carboxylate (182 mg) in EtOAc (0.7 ml) and water (0.09 ml) was added 4N hydrogen chloride in EtOAc (0.7 ml) and the mixture was stirred at room temperature for 2 hours. Solvent was removed in vacuo to give 4-methoxy-4-(1-methyl-1H-imidazol-2-yl)piperidine dihydrochloride (122 mg) as a colorless powder. The obtained crude product was used in next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08603975B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-7bc64af39f604b6d96b2599468b9f6b9 |
| Source note | uspto-grants-2013_12 |