Methanol → 1-(2-{4-[(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]piperidin-1-yl}ethyl)-7-methoxy-1,8-naphthyridin-2(1H)-one

HRID 191040Notes

Reaction equation

HRID 191040 reaction equation
[CH3:33][O-:34].[CH3:36][OH:37].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][c:8](=[O:32])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH:20][CH2:21][c:22]4[cH:23][c:24]5[c:25]([cH:26][n:27]4)[O:28][CH2:29][CH2:30][O:31]5)[CH2:18][CH2:19]3)[c:10]2[n:11]1.[Na+:35]>>[c:2]1([O:34][CH3:33])[cH:3][cH:4][c:5]2[cH:6][cH:7][c:8](=[O:32])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH:20][CH2:21][c:22]4[cH:23][c:24]5[c:25]([cH:26][n:27]4)[O:28][CH2:29][CH2:30][O:31]5)[CH2:18][CH2:19]3)[c:10]2[n:11]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 3826051MethoxideHCID 159824067-Chloro-1-(2-{4-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]piperidin-1-yl}ethyl)-1,8-naphthyridin-2(1H)-one

Product 1

HCID 159824071-(2-{4-[(2,3-Dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]piperidin-1-yl}ethyl)-7-methoxy-1,8-naphthyridin-2(1H)-one

Sources & evidence

ORD record
ord-b7e98a64dc62411bb20b5fe633a4980c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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