1,3-Propanediamine → HCID 71548631, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 1-1 in Scheme 1 by using 2,4-dichlorothieno[3,2-d]pyrimidine and propane-1,3-diamine, followed by reaction with 2,3,4,5-tetrahydro-1,4-benzothiazepine-1-oxide. MS obsd. (ESI+) [(M+H)+] 388, 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.73-7.78 (m, 2H), 7.71 (d, J=8.3 Hz, 1H), 7.43-7.52 (m, 2H), 7.11 (d, J=5.3 Hz, 1H), 5.24 (d, J=15.2 Hz, 2H), 3.68-3.74 (m, 2H), 3.50 (br. s., 2H), 3.46 (br. s., 2H), 2.93 (t, J=7.6 Hz, 2H), 1.93-2.03 (m, 2H)

Provenance & Evidence