1,3-Propanediamine → N-[2-(1,2,3,5-Tetrahydro-4H-1,4-benzodiazepin-4-yl)thieno[3,2-d]pyrimidin-4-yl]propane-1,3-diamine

Participants

Reaction Steps

The title compound was prepared in analogy to Example 1-1 in Scheme 1 by using 2,4-dichlorothieno[3,2-d]pyrimidine and propane-1,3-diamine, followed by reaction with 2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine. MS obsd. (ESI+) [(M+H)+] 355, 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.71 (d, J=5.6 Hz, 1H), 7.37 (d, J=7.1 Hz, 1H), 7.08 (d, J=5.3 Hz, 1H), 7.02-7.07 (m, 1H), 6.79-6.86 (m, 2H), 4.85 (s, 2H), 4.04-4.09 (m, 2H), 3.73 (t, J=6.6 Hz, 2H), 3.20-3.24 (m, 2H), 2.86-2.92 (m, 2H), 1.93-2.03 (m, 2H).

Provenance & Evidence