2,4-Dichlorothieno[3,2-d]pyrimidine → HCID 71548938, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example-1 in Scheme 1 by using 2,4-dichlorothieno[3,2-d]pyrimidine and propane-1,3-diamne, followed by reaction with 5,5-difluoro-2,3,4,5-tetrahydro-1H-benzo[c]azepine. MS obsd. (ESI+) [(M+H)+]390, 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.71 (d, J=5.6 Hz, 1H), 7.60 (d, J=7.8 Hz, 1H), 7.55 (d, J=7.3 Hz, 1H), 7.35-7.41 (m, 1H), 7.27-7.34 (m, 1H), 7.08 (d, J=5.3 Hz, 1H), 4.97 (s, 2H), 4.23-4.31 (m, 2H), 3.70 (t, J=6.6 Hz, 2H), 2.86 (t, J=7.5 Hz, 2H), 2.41-2.53 (m, 2H), 1.94 (m, 2H).

Provenance & Evidence