Water → HCID 86680733, compound

Participants

Reaction Steps

To a mixture of 3-aminomethyloxetan-3-ylamine (0.98 g, 9.6 mmol) in dichloromethane (15 mL) and triethylamine (4 mL, 28.7 mol) was added a solution of 2,4-dichlorothieno[3,2-d]pyrimidine (1.0 g, 4.8 mmol) dropwise in dichloromethane (5 mL). The mixture was stirred at room temperature overnight, then water (50 mL) was added. The mixture was extracted with dichloromethane. The organic phase was washed with brine, dried with anhydrous sodium sulfate. The solvent was then removed and the residue was purified by flash column chromatography (eluting with 10%˜30% methanol in dichloromethane) to give 1.0 g of N-[(3-aminooxetan-3-yl)methyl]-2-chlorothieno[3,2-d]pyrimidin-4-amine and N-[3-(aminomethyl)oxetan-3-yl]-2-chlorothieno[3,2-d]pyrimidin-4-amine (yield was 77%). MS obsd. (ESI+) [(M+H)+] 271.

Provenance & Evidence