2,3,4,5-Tetrahydrobenzo[F][1,4]thiazepine 1,1-dioxide → HCID 71548636, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[(3-aminooxetan-3-yl)methyl]-2-chlorothieno[3,2-d]pyrimidin-4-amine and N-[3-(aminomethyl)oxetan-3-yl]-2-chlorothieno[3,2-d]pyrimidin-4-amine (184 mg, 0.66 mmol), 6,7,8,9-tetrahydro-5-thia-8-aza-benzocycloheptene-5,5-dioxide (680 mg, 3.44 mmol) in n-Butanol (1 mL) was heated at 160° C. for 30 min. The crude was purified by preparative HPLC to afford N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno[3,2-d]pyrimidin-4-amine and N-[3-(aminomethyl)oxetan-3-yl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)thieno[3,2-d]pyrimidin-4-amine.

Provenance & Evidence