[3-(Aminomethyl)oxetan-3-yl]methanamine → HCID 71548787, compound

HRID 1910457Notes

Reaction equation

HRID 1910457 reaction equation
[O:1]=[S:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][N:5]([C:13]2[NH:14][C:15](=O)[C:16]3[S:21][C:20]([CH3:22])=[CH:19][C:17]=3[N:18]=2)[CH2:4][CH2:3]1.[O:24]1[CH2:27][C:26]([CH2:30][NH2:31])([CH2:28][NH2:29])[CH2:25]1>>[NH2:29][CH2:28][C:26]1([CH2:30][NH:31][C:15]2[C:16]3[S:21][C:20]([CH3:22])=[CH:19][C:17]=3[N:18]=[C:13]([N:5]3[CH2:6][C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=4[S:2](=[O:1])[CH2:3][CH2:4]3)[N:14]=2)[CH2:27][O:24][CH2:25]1

Participants

3

Reactant 2

HCID 10953471[3-(Aminomethyl)oxetan-3-yl]methanamineHCID 1363597882-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylthieno[3,2-d]pyrimidin-4(3H)-one

Product 1

HCID 71548787HCID 71548787, compound

Procedure

The title compound was prepared in analogy to Example 3-1 in Scheme 3 by using 2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylthieno[3,2-d]pyrimidin-4(3H)-one and 3,3-oxetanedimethanamine. MS obsd. (ESI+) [(M+H)+] 444, 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.74 (t, J=8.7 Hz, 2H), 7.43-7.51 (m, 2H), 6.83 (s, 1H), 5.21 (d, J=15.2 Hz, 1H), 4.68-4.75 (m, 1H), 4.64 (d, J=6.6 Hz, 2H), 4.50 (t, J=6.2 Hz, 2H), 4.01 (br. s., 2H), 3.09 (s, 2H), 2.56 (s, 3H), 2.06 (s, 4H).

Sources & evidence

ORD record
ord-b059a5cabc1948268224106744e5267e
Source dataset
uspto-grants-2013_12
Patent number
US08604019B2

Reaction notes

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