2-Chloroacetophenone → HCID 86672926, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (55.0 mg, 0.36 mmol) was added to a solution of (R)-benzhydryl quinuclidin-3-ylcarbamate (100 mg, 0.30 mmol, prepared as in example 2) in ethyl acetate (4 ml). The reaction was stirred at room temperature overnight. The suspension was decanted, solvent was removed, and the product was evaporated to dryness. Et2O was added, and the suspension was sonicated. The precipitate was collected by suction filtration and dried under vacuum at 40° C. to obtain (R)-3-(benzhydryloxycarbonylamino)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo-[2.2.2]octane chloride (110 mg)

Provenance & Evidence