2-Chloroacetophenone → HCID 70673624, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (13 mg, 0.09 mmol) was added to a solution of (R)-bis(4-fluorophenyl)methyl quinuclidin-3-ylcarbamate (32.0 mg, 0.09 mmol, prepared as in example 3) in ethyl acetate (2 ml). The reaction was stirred at room temperature overnight. Then more 2-chloro-1-phenylethanone (2.7 mg, 0.02 mmol) was added to the solution, and the reaction was stirred for additional 24 hours. The reaction was evaporated to dryness, and the residue was triturated in Et2O. Then isopropyl ether was added, and the product was sonicated and the precipitate was collected by suction filtration to obtain (R)-3-((bis(4-fluorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (32.4 mg)

Provenance & Evidence