2-(Chloroacetyl)thiophene → HCID 86672928, compound

Participants

Reaction Steps

2-Chloro-1-(thiophen-2-yl)ethanone (12.0 mg, 0.07 mmol) was added to a solution of (4-methoxyphenyl)(phenyl)methyl(R)-quinuclidin-3-ylcarbamate (22.0 mg, 0.06 mmol, prepared as in example 3) in ethyl acetate (2 ml). The reaction was stirred at room temperature for two days. The reaction was evaporated to dryness. The crude was purified by flash chromatography (DCM/MeOH=95/5) to obtain (3R)-3-(((4-methoxyphenyl)(phenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (23 mg, mixture of diastereoisomers).

Provenance & Evidence