2-(Chloroacetyl)thiophene → HCID 86672932, compound

Participants

Reaction Steps

To a solution of (2-chlorophenyl)(4-chlorophenyl)methyl(R)-quinuclidin-3-ylcarbamate (95.0 mg, 0.23 mmol) in ethyl acetate (3 ml), 2-chloro-1-(thiophen-2-yl)ethanone (37.6 mg, 0.23 mmol) was added, and the mixture was stirred at room temperature overnight. The solvent was removed under vacuum, and the residue was taken up in diethyl ether and filtered. The product was purified by flash chromatography (DCM/MeOH=95/5) to obtain (3R)-3-(((2-chlorophenyl)(4-chlorophenyl)methoxy)carbonylamino)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (45.0 mg, mixture of diastereoisomers).

Provenance & Evidence