2-(Chloroacetyl)thiophene → HCID 86672934, compound

Participants

Reaction Steps

2-Chloro-1-(thiophen-2-yl)ethanone (30.2 mg, 0.19 mmol) was added to a solution of (R)-thiophen-2-ylmethyl quinuclidin-3-ylcarbamate (50.0 mg, 0.19 mmol) in EtOAc (3 ml). The reaction was stirred at room temperature overnight. The solvent was removed, and the residue was triturated in Et2O, filtered and dried to give (R)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-3-((thiophen-2-ylmethoxy)carbonylamino)-1-azoniabicyclo[2.2.2]octane chloride (60 mg).

Provenance & Evidence