2-(Chloroacetyl)thiophene → HCID 70673626, compound

Participants

Reaction Steps

To a solution of (R)—O-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamothioate (60 mg, 0.15 mmol) in ethyl acetate (1 ml), 2-chloro-1-(thiophen-2-yl)ethanone (27.3 mg, 0.17 mmol) was added. The reaction was stirred at room temperature for 3 days. The solvent was evaporated, and the residue was purified by flash chromatography (DCM/MeOH=75/25) to obtain (R)-3-((bis(3-fluorophenyl)methoxy)carbonothioylamino)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (20 mg).

Provenance & Evidence