Methyl iodide → HCID 70673628, compound

Participants

Reaction Steps

To a solution of (R)-bis(3-fluorophenyl)methyl 1-benzylpyrrolidin-3-ylcarbamate (300 mg, 0.71 mmol) in EtOAc (9 ml), iodomethane (44.2 μl, 0.71 mmol) was added, and the reaction was stirred at room temperature overnight. The solvent was then removed under vacuum, and the residue was triturated with diethyl ether. The product was purified by flash chromatography (DCM/MeOH=99/1) and then by preparative HPLC to give (3R)-1-benzyl-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-methylpyrrolidinium iodide (25 mg).

Provenance & Evidence